The Universal and DreamWorks Animation movie continues its success, contributing to the franchise's impressive $1.9 billion box office haul since its launch in 2008.
With a domestic total of $107.7 million already, the fourth installment proves its enduring popularity.
Despite new releases like "Arthur the King" and "Love Lies Bleeding," established franchises like "Dune: Part Two" remain strong contenders.
Arthur the King" debuts in third place with $7.5 million, buoyed by positive audience reception with an A CinemaScore.
Love Lies Bleeding" and "The American Society of Magical Negroes" also enter the box office, though with more modest earnings.
As the industry awaits upcoming releases like "Ghostbusters: Frozen Empire" and "Godzilla x Kong: The New Empire," analysts anticipate a slower period until the summer movie season.
Final box office figures will be revealed on Monday.